![]() Retinal tissue histology has contributed to our understanding of retinal cellular mechanisms and disease pathophysiology. Histological evaluation of retinal tissue in animal models has traditionally been the primary method for investigating the microstructure of the retina. Although SD-OCT provides non-invasive histological–grade sections of the rodent posterior segment, image acquisition is technologically cumbersome as human devices are retrofitted for animal use. The rapid, high resolution, non-invasive cross sectional images produced by SD-OCT is an important tool in diagnosing posterior segment pathology and monitoring it longitudinally. Spectral-domain optical coherence tomography (SD-OCT) is an important imaging modality, in clinical ophthalmology and animal research, for characterizing morphology and understanding pathophysiological changes in the retina. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. All relevant data are within the paper.įunding: The Department of Ophthalmology Jacksonville, Jacksonville, Florida provided all financial support for this study. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The authors confirm that all data underlying the findings are fully available without restriction. Received: JAccepted: SeptemPublished: October 31, 2014Ĭopyright: © 2014 Ferguson et al. PLoS ONE 9(10):Įditor: Knut Stieger, Justus-Liebig-University Giessen, Germany Citation: Ferguson LR, Grover S, Dominguez II JM, Balaiya S, Chalam KV (2014) Retinal Thickness Measurement Obtained with Spectral Domain Optical Coherence Tomography Assisted Optical Biopsy Accurately Correlates with Ex Vivo Histology.
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